Comparative genomics of pAKD4, the prototype IncP-1δplasmid with a complete backbone
PAK4 is constitutively phosphorylated on serine 474 (Ser-474) and it is maintained inactive through an auto-inhibitory N-terminal domain (AID).Once Rac/CDC42 Rho GTPase binds to the p21 binding domain (PBD), the AID-mediated inhibition will be released thus the kinase will be fully activated and will phosphorylate a set of biochemical substrates associated with the regulation of cell growth ...
Comparative genomics of pAKD4, the prototype IncP-1delta ... - PubMed
nucleotide sequence of a new IncP-1δ plasmid pAKD4 to the genomes of other IncP-1 plasmids. Plasmid pAKD4 was previously isolated by exogenous plasmid isolation from an agricultural soil in...
Comparative genomics of pAKD4, the prototype IncP-1δ plasmid with a ...
Phylogenetic analysis of plasmid pAKD4—To confirm that pAKD4 is an IncP-1 plasmid, a maximum likelihood tree was inferred from concatenated sequences of 20 backbone proteins shared by all IncP-1 plasmids and pAKD4 (Fig. 3).
Genetic map of pAKD4. Coding regions are illustrated by ... - ResearchGate
The recombination appears to have been between the ancestor of the IncP-1α plasmids and an IncP-1δ plasmid similar to pAKD4. Visual inspection of the aligned trbB genes also clearly showed a recombination event that included pAKD4, several of the IncP-1β plasmids, and the ancestor of the IncP-1ε plasmids, which would help explain the highly ...
Comparative genomics of pAKD4, the prototype IncP-1delta plasmid with a ...
We conclude that pAKD4 and pIJB1 are new members of the IncP-1δ sub-group. Since pAKD4 is the only plasmid of the three with a complete set of typical IncP-1δ- like transfer genes and is self-transferable, we propose it to be the prototype plasmid for the IncP-1δ subgroup.
Comparative genomics of pAKD4, the prototype IncP-1δ plasmid with a ...
View publication. Phylogenetic tree showing the relationship of the 12 pAKD plasmids described in this study and pAKD4 (27) (bold) with other completely sequenced IncP-1 plasmids. A maximum ...
Inferring the Evolutionary History of IncP-1 Plasmids Despite ...
Phylogenetic analysis of plasmid pAKD4— To confirm that pAKD4 is an IncP-1 δ plasmid, a maximum likelihood tree was inferred from concatenated sequences of 20 backbone proteins shared by all ...
Broad-Host-Range Plasmids from Agricultural Soils Have IncP-1 Backbones ...
P21-activated protein kinases (PAKs) are thought to be at the center of tumor signaling pathways. As a representative member of the group II PAK family, P21-activated protein kinase 4 (PAK4) plays an important role in the development of tumors, with several biological functions such as participating in oncogenic transformation, promoting cell division, resisting aging and apoptosis, regulating ...
Comparative genomics of pAKD4, the prototype IncP-1δ plasmid with a ...
We conclude that pAKD4 and pIJB1 are new members of the IncP-1δ sub-group. Since pAKD4 is the only plasmid of the three with a complete set of typical IncP-1δ-like transfer genes and is self-transferable, we propose it to be the prototype plasmid for the IncP-1δ sub-group. 2. Materials and methods. 2.1.
Figure 3 from Comparative genomics of pAKD4, the prototype IncP-1delta ...
PAK4 (P21 (RAC1) Activated Kinase 4) is a Protein Coding gene. Diseases associated with PAK4 include Adenomyosis and Parameningeal Embryonal Rhabdomyosarcoma.Among its related pathways are Integrin Pathway and GPCR Pathway.Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.